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Tuesday, January 27, 2026 13:00to14:30

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The Metabolism-First hypothesis for the origin of life posits that organic chemical reaction networks originated in geochemistry and became more complex through catalytic feedback effects. This process would lead to increasing autonomy from the original environment, ultimately resulting in the metabolic pathways found in chemoautotrophic organisms and a free-standing cell replete with catalysts for its own reactions (coenzymes, enzymes and genes). This hypothesis connects well with early microbial physiology – a weakness of other hypotheses.

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